Hwayeon Ryu, Assistant Professor of Mathematics, published a paper in Journal of Theoretical Biology on investigating macrophage polarization process in microenvironment.
Assistant Professor of Mathematics Hwayeon Ryu has published a peer-reviewed paper entitled “Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization” in Journal of Theoretical Biology, one of prestigious journals in the field of mathematical biology.
This work was from international collaboration with three other mathematical biologists including Susanna Röblitz at the University of Bergen in Norway as well as a biologist, Ryan Snodgrass, at Goethe-University in Germany. In this collaboration, Ryu and co-authors identify multistable dynamics in macrophage polarization model, which help them formulate hypotheses to guide the conduction of future laboratory experiments. They are currently extending this work by considering stochastic behaviors in the macrophage polarization process.
Journal of Theoretical Biology, established in 1961, is one of highly cited, top journals in the field of mathematical biology. It is a biweekly peer-reviewed scientific journal covering theoretical biology, as well as mathematical, computational and statistical aspects of biology. Some research areas covered by the journal include cell biology, evolutionary biology, population genetics, morphogenesis, and immunology.
A. S. Frank, K. Larripa, H. Ryu, R. G. Snodgrass, and S. Röblitz, Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization